The 2022 introduction of universal self-collection has been a game-changer in testing for HPV Human Papillomavirus. It has increased engagement and satisfaction with screening, especially for those in regional areas, people with disabilities, and Aboriginal and Torres Strait Islander communities.  In September 2024, a nationwide campaign promoting self-collection was launched. As demand grew exponentially the ACPCC Australian Centre for the Prevention of Cervical Cancer led the expert group with resources and training to help support Australian health care providers in offering patients more choice in how they engage with cervical screening. Moreover, we are proud to be the first laboratory in Australia accredited by the National Association of Testing Authorities to process self-collected HPV samples. This accreditation enables us to handle high volumes of samples, which is essential as demand continues to grow. Over the past financial year, the ACPCC Australian Centre for the Prevention of Cervical Cancer, operating under the Victorian Cancer Screening Framework, delivered substantial public health benefits to Victorians through our leadership in cancer screening data, education, and service innovation. The ACPCC Australian Centre for the Prevention of Cervical Cancer’s stewardship of the Victorian Cancer Screening Annual Statistical Report provided the first interactive dataset integrating cervical, bowel, and breast screening metrics in Australia, enabling targeted interventions and policy refinement.  Our collaborative partnerships with the Victorian Aboriginal Community Controlled Health Organisation, BreastScreen Victoria, and Cancer Council Victoria further strengthened workforce capability and community engagement. These efforts collectively enhanced early detection, improved follow-up care, and supported Victoria’s goal of eliminating cervical cancer as a public health problem. The year-long ‘Own It’ campaign was the first national cervical screening campaign in over 25 years. Funded by the Commonwealth Department of Health, and working with key stakeholders, the ACPCC Australian Centre for the Prevention of Cervical Cancer’s role was to deliver the health care provider-facing phase of the campaign. The campaign supported the Government’s policy of increased self-collection, allowing women and people with a cervix to perform their own test privately at their local clinic. Self-collection was disproportionately taken up by under-screened and never-screened people, improving equitable access to cervical screening, as called for in the National Elimination Strategy. ‘Own It’ also supported the National Elimination Strategy by emphasising equity of access to culturally safe and inclusive services. By focusing on Aboriginal and Torres Strait Islander and multicultural communities, as well as people of diverse sexuality and gender identity, the campaign helped close gaps in screening participation and brought us closer to eliminating cervical cancer for all Australians. Australia is on track to be the first country to reach cervical cancer elimination, thanks to effective screening, widespread HPV vaccination, and strong public health leadership. At the ACPCC Australian Centre for the Prevention of Cervical Cancerwe are deeply committed to supporting these programs, and we are working with both national and international partners to meet the WHO World Health Organization’s elimination targets. This year we were listed by WHO World Health Organizationas an HPV Human Papillomavirus Performance Evaluation Laboratory, one of four globally. The Elimination Partnership in the Indo-Pacific for Cervical Cancer consortium is a powerful international collaboration. It brings together leading institutions such as the University of Sydney, the Kirby Institute, Family Planning Australia, and the ACPCC Australian Centre for the Prevention of Cervical Cancer, along with Unitaid and the National Centre for Immunisation Research and Surveillance. With support from the Minderoo Foundation and the Department of Foreign affairs and Trade, we are assisting partner countries across the Asia-Pacific region to implement, expand and sustain cervical cancer elimination programs. We are honoured to be part of a global movement to eliminate cervical cancer. Our work integrates translational research with clinical practice and public health policy. With continued collaboration and innovation, we believe we can ensure that women and people with a cervix everywhere are freed from the fear and the burden of cervical cancer. We are incredibly proud of the work we do. Our 2025 Annual Report highlights this year’s achievements and the work we are continuing to undertake to reach elimination targets in Victoria, Australia and across our region.